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Future Med Chem ; 6(13): 1481-3, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25365232

RESUMO

Salvador Moncada studied medicine at the University of El Salvador (El Salvador) before coming to the UK in 1971 to work on a PhD with Professor John Vane at the Institute of Basic Medical Sciences, Royal College of Surgeons (UK). After a short period of research at the University of Honduras (Honduras), he joined the Wellcome Research Laboratories (UK) where he became Head of the Department of Prostaglandin Research and later, Director of Research. He returned to academic life in 1996 as founder and director of the Wolfson Institute for Biomedical Research at University College London (UK). Moncada played a role in the discovery of the mechanism of action of aspirin-like drugs and later led the teams which discover prostacyclin and identified nitric oxide as a biological mediator. In his role as a Director of Research of the Wellcome Laboratories, he oversaw the discovery and development of medicines for epilepsy, migraine, malaria and cancer. Currently, he is working on the regulation of cell proliferation as Director of the Institute of Cancer Sciences at the University of Manchester (UK). Moncada has won numerous awards from the international scientific community and in 2010, he received a knighthood from Her Majesty Queen Elizabeth II for his services to science.


Assuntos
Química Farmacêutica , Descoberta de Drogas , Anti-Hipertensivos/história , Anti-Hipertensivos/uso terapêutico , Pesquisa Biomédica/história , Pesquisa Biomédica/métodos , Química Farmacêutica/história , Química Farmacêutica/métodos , Descoberta de Drogas/história , Descoberta de Drogas/métodos , Fatores Relaxantes Dependentes do Endotélio/história , Fatores Relaxantes Dependentes do Endotélio/metabolismo , Epoprostenol/história , Epoprostenol/uso terapêutico , História do Século XX , História do Século XXI , Humanos , Neoplasias/diagnóstico , Neoplasias/terapia , Óxido Nítrico/história , Óxido Nítrico/metabolismo
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